Malaria Blood Cell Image Classification Using ResNet50V2 Based on Transfer Learning with Web Application Implementation

Penulis

  • Rika Agisha Siti Nurazizah Universitas Nusa Putra, Sukabumi, Indonesia
  • Adhi Kusnadi Universitas Nusa Putra, Sukabumi, Indonesia

DOI:

https://doi.org/10.33751/jhss.v10i03.267

Kata Kunci:

image classification, malaria, ResNet50V2, transfer learning, deep learning, web application.

Abstrak

Malaria remains an infectious disease that requires a fast and accurate diagnostic process, particularly in areas with limited access to skilled microscopists. Microscopic examination as a conventional diagnostic method still has several limitations, including dependence on the expertise of laboratory analysts, relatively long examination time, and the potential for interpretation errors. This study aims to develop a malaria blood cell image classification system using a deep learning-based transfer learning approach with the ResNet50V2 architecture and to compare its performance with MobileNetV2 as the baseline model. The dataset used in this study was the NIH Malaria Cell Images Dataset, consisting of 27,558 red blood cell images categorized into two classes: Parasitized and Uninfected. The research stages included image preprocessing, data augmentation, dataset splitting with a 70:15:15 ratio, model training, performance evaluation, and implementation of the best-performing model into a web-based application. The evaluation was conducted using accuracy, precision, recall, F1-score, confusion matrix, and ROC-AUC metrics. The results showed that ResNet50V2 achieved an accuracy of 93.76%, precision of 93.81%, recall of 93.76%, F1-score of 93.76%, and an AUC of 0.985. Meanwhile, MobileNetV2 obtained an accuracy of 93.06%, precision of 93.22%, recall of 93.05%, F1-score of 93.05%, and an AUC of 0.980. ResNet50V2 also produced a lower number of false negatives than MobileNetV2, making it more suitable for supporting the detection of malaria-infected blood cell images. The best-performing model was then implemented into a web-based application using Flask API. The findings indicate that ResNet50V2 has the potential to be used as a decision support system for early malaria screening based on digital images, although further clinical validation is still required before implementation in real medical environments.

Referensi

Bibin, D., Nair, M. S., & Punitha, P. (2017). Malaria parasite detection from peripheral blood smear images using deep belief networks. IEEE Access, 5, 9099–9108. https://doi.org/10.1109/ACCESS.2017.2705642

Bradley, A. P. (1997). The use of the area under the ROC curve in the evaluation of machine learning algorithms. Pattern Recognition, 30(7), 1145–1159. https://doi.org/10.1016/S0031-3203(96)00142-2

Chicco, D., & Jurman, G. (2020). The advantages of the Matthews correlation coefficient over F1 score and accuracy in binary classification evaluation. BMC Genomics, 21, Article 6. https://doi.org/10.1186/s12864-019-6413-7

Ching, T., Himmelstein, D. S., Beaulieu-Jones, B. K., Kalinin, A. A., Do, B. T., Way, G. P., Ferrero, E., Agapow, P. M., Zietz, M., Hoffman, M. M., Xie, W., Rosen, G. L., Lengerich, B. J., Israeli, J., Lanchantin, J., Woloszynek, S., Carpenter, A. E., Shrikumar, A., Xu, J., ... Greene, C. S. (2018). Opportunities and obstacles for deep learning in biology and medicine. Journal of The Royal Society Interface, 15(141), Article 20170387. https://doi.org/10.1098/rsif.2017.0387

Chollet, F. (2017). Xception: Deep learning with depthwise separable convolutions. In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition (pp. 1251–1258). https://doi.org/10.1109/CVPR.2017.195

Cibulskis, R. E., Alonso, P., Aponte, J., Aregawi, M., Barrette, A., Bergeron, L., Fergus, C. A., Knox, T., Lynch, M., Patouillard, E., Schwarte, S., Stewart, S., & Williams, R. (2016). Malaria: Global progress 2000–2015 and future challenges. Infectious Diseases of Poverty, 5, Article 61. https://doi.org/10.1186/s40249-016-0151-8

Deng, J., Dong, W., Socher, R., Li, L. J., Li, K., & Fei-Fei, L. (2009). ImageNet: A large-scale hierarchical image database. In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition (pp. 248–255). https://doi.org/10.1109/CVPR.2009.5206848

Dong, Y., Jiang, Z., Shen, H., Pan, W. D., Williams, L. A., Reddy, V. V. B., Benjamin, W. H., & Bryan, A. W. (2017). Evaluations of deep convolutional neural networks for automatic identification of malaria infected cells. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp. 101–104). https://doi.org/10.1109/EMBC.2017.8036814

Esteva, A., Kuprel, B., Novoa, R. A., Ko, J., Swetter, S. M., Blau, H. M., & Thrun, S. (2017). Dermatologist-level classification of skin cancer with deep neural networks. Nature, 542(7639), 115–118. https://doi.org/10.1038/nature21056

Fawcett, T. (2006). An introduction to ROC analysis. Pattern Recognition Letters, 27(8), 861–874. https://doi.org/10.1016/j.patrec.2005.10.010

Gopakumar, G. P., Swetha, M., Siva, G. S., & Sai Subrahmanyam, G. R. K. (2018). Convolutional neural network-based malaria diagnosis from focus stack of blood smear images acquired using custom-built slide scanner. Journal of Biophotonics, 11(3), Article e201700003. https://doi.org/10.1002/jbio.201700003

He, K., Zhang, X., Ren, S., & Sun, J. (2016a). Deep residual learning for image recognition. In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition (pp. 770–778). https://doi.org/10.1109/CVPR.2016.90

He, K., Zhang, X., Ren, S., & Sun, J. (2016b). Identity mappings in deep residual networks. In Lecture Notes in Computer Science: Vol. 9908 (pp. 630–645). Springer. https://doi.org/10.1007/978-3-319-46493-0_38

Huang, G., Liu, Z., Van Der Maaten, L., & Weinberger, K. Q. (2017). Densely connected convolutional networks. In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition (pp. 4700–4708). https://doi.org/10.1109/CVPR.2017.243

Kelly, C. J., Karthikesalingam, A., Suleyman, M., Corrado, G., & King, D. (2019). Key challenges for delivering clinical impact with artificial intelligence. BMC Medicine, 17, Article 195. https://doi.org/10.1186/s12916-019-1426-2

Kingma, D. P., & Ba, J. (2015). Adam: A method for stochastic optimization. In Proceedings of the 3rd International Conference on Learning Representations. https://arxiv.org/abs/1412.6980

LeCun, Y., Bengio, Y., & Hinton, G. (2015). Deep learning. Nature, 521(7553), 436–444. https://doi.org/10.1038/nature14539

Litjens, G., Kooi, T., Bejnordi, B. E., Setio, A. A. A., Ciompi, F., Ghafoorian, M., Van Der Laak, J. A. W. M., Van Ginneken, B., & Sánchez, C. I. (2017). A survey on deep learning in medical image analysis. Medical Image Analysis, 42, 60–88. https://doi.org/10.1016/j.media.2017.07.005

Liu, X., Faes, L., Kale, A. U., Wagner, S. K., Fu, D. J., Bruynseels, A., Mahendiran, T., Moraes, G., Shamdas, M., Kern, C., Ledsam, J. R., Schmid, M. K., Balaskas, K., Topol, E. J., Bachmann, L. M., Keane, P. A., & Denniston, A. K. (2019). A comparison of deep learning performance against health-care professionals in detecting diseases from medical imaging: A systematic review and meta-analysis. The Lancet Digital Health, 1(6), e271–e297. https://doi.org/10.1016/S2589-7500(19)30123-2

Moody, A. (2002). Rapid diagnostic tests for malaria parasites. Clinical Microbiology Reviews, 15(1), 66–78. https://doi.org/10.1128/CMR.15.1.66-78.2002

Pan, S. J., & Yang, Q. (2010). A survey on transfer learning. IEEE Transactions on Knowledge and Data Engineering, 22(10), 1345–1359. https://doi.org/10.1109/TKDE.2009.191

Poostchi, M., Silamut, K., Maude, R. J., Jaeger, S., & Thoma, G. (2018). Image analysis and machine learning for detecting malaria. Malaria Journal, 17, Article 177. https://doi.org/10.1186/s12936-018-2492-9

Rajaraman, S., Antani, S. K., Poostchi, M., Silamut, K., Hossain, M. A., Maude, R. J., Jaeger, S., & Thoma, G. R. (2018). Pre-trained convolutional neural networks as feature extractors toward improved malaria parasite detection in thin blood smear images. PeerJ, 6, Article e4568. https://doi.org/10.7717/peerj.4568

Roberts, M., Driggs, D., Thorpe, M., Gilbey, J., Yeung, M., Ursprung, S., Aviles-Rivero, A. I., Etmann, C., McCague, C., Beer, L., Weir-McCall, J. R., Teng, Z., Gkrania-Klotsas, E., Rudd, J. H. F., Sala, E., & Schönlieb, C. B. (2021). Common pitfalls and recommendations for using machine learning to detect and prognosticate for COVID-19 using chest radiographs and CT scans. Nature Machine Intelligence, 3, 199–217. https://doi.org/10.1038/s42256-021-00307-0

Saito, T., & Rehmsmeier, M. (2015). The precision-recall plot is more informative than the ROC plot when evaluating binary classifiers on imbalanced datasets. PLOS ONE, 10(3), Article e0118432. https://doi.org/10.1371/journal.pone.0118432

Sandler, M., Howard, A., Zhu, M., Zhmoginov, A., & Chen, L. C. (2018). MobileNetV2: Inverted residuals and linear bottlenecks. In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition (pp. 4510–4520). https://doi.org/10.1109/CVPR.2018.00474

Shorten, C., & Khoshgoftaar, T. M. (2019). A survey on image data augmentation for deep learning. Journal of Big Data, 6, Article 60. https://doi.org/10.1186/s40537-019-0197-0

Srivastava, N., Hinton, G., Krizhevsky, A., Sutskever, I., & Salakhutdinov, R. (2014). Dropout: A simple way to prevent neural networks from overfitting. Journal of Machine Learning Research, 15, 1929–1958.

Tangpukdee, N., Duangdee, C., Wilairatana, P., & Krudsood, S. (2009). Malaria diagnosis: A brief review. The Korean Journal of Parasitology, 47(2), 93–102. https://doi.org/10.3347/kjp.2009.47.2.93

Topol, E. J. (2019). High-performance medicine: The convergence of human and artificial intelligence. Nature Medicine, 25(1), 44–56. https://doi.org/10.1038/s41591-018-0300-7

Wiens, J., Saria, S., Sendak, M., Ghassemi, M., Liu, V. X., Doshi-Velez, F., Jung, K., Heller, K., Kale, D., Saeed, M., Ossorio, P. N., & Goldenberg, A. (2019). Do no harm: A roadmap for responsible machine learning for health care. Nature Medicine, 25(9), 1337–1340. https://doi.org/10.1038/s41591-019-0548-6

Wongsrichanalai, C., Barcus, M. J., Muth, S., Sutamihardja, A., & Wernsdorfer, W. H. (2007). A review of malaria diagnostic tools: Microscopy and rapid diagnostic test. The American Journal of Tropical Medicine and Hygiene, 77(6 Suppl), 119–127. https://doi.org/10.4269/ajtmh.2007.77.119

World Health Organization. (2025). World malaria report 2025. World Health Organization.

Yu, K. H., Beam, A. L., & Kohane, I. S. (2018). Artificial intelligence in healthcare. Nature Biomedical Engineering, 2(10), 719–731. https://doi.org/10.1038/s41551-018-0305-z

Diterbitkan

2026-07-23

Cara Mengutip

Nurazizah, R. A. S., & Kusnadi, A. . (2026). Malaria Blood Cell Image Classification Using ResNet50V2 Based on Transfer Learning with Web Application Implementation. JHSS (JOURNAL OF HUMANITIES AND SOCIAL STUDIES), 10(03), 849–856. https://doi.org/10.33751/jhss.v10i03.267